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Hepatitis C

(HCV; Hep C)

Definition

Hepatitis C is an infection of the liver with the hepatitis C virus (HCV).
Hepatitis
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Causes

The hepatitis C virus is spread through contact with the blood of an infected person.
A woman with hepatitis can pass the virus on to her baby during birth. The hepatitis C virus is not spread through food or water.

Risk Factors

Factors that increase your chance of this infection:

Symptoms

Most people with hepatitis C do not have symptoms. Over time, the disease can cause serious liver damage.
Symptoms may include:
Chronic hepatitis C may cause some of the above symptoms, as well as:
Serious complications of hepatitis C include:

Diagnosis

You will be asked about your symptoms and medical history. A physical exam will be done. You will also discuss your risk factors.
Your bodily fluids and tissues may be tested. This can be done with:
Your liver function may be evaluated. This can be done with liver function studies.
Images may be needed of your liver. This can be done with an ultrasound.

Treatment

Hepatitis C is usually treated with combined therapy, consisting of:
These medications can cause difficult side effects. They also have limited success rates.
You will be advised to stop drinking alcohol and smoking, which can further damage your liver, especially when undergoing treatment. If you have problems stopping alcohol, your doctor can refer you to counseling or a treatment program. There are several ways to successfully quit smoking .
In unsuccessful cases, chronic hepatitis C can cause cirrhosis and serious liver damage. A liver transplant may be needed, although it does not typically cure hepatitis C.

Prevention

To prevent becoming infected with hepatitis C:
To prevent spreading hepatitis C to others if you are infected:

RESOURCES

American Liver Foundation http://www.liverfoundation.org

Hepatitis Foundation International http://www.hepfi.org

CANADIAN RESOURCES

Canadian Liver Foundation http://www.liver.ca

Health Canada http://www.hc-sc.gc.ca

References

Chang MH, Gordon LA, Fung HB. Boceprevir: A protease inhibitor for the treatment of hepatitis C. Clin Ther. 2012 Sep 10. pii: S0149-2918(12)00490-0. doi: 10.1016/j.clinthera.2012.08.009. [Epub ahead of print]

Hepatitis C. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated September 25, 2014. Accessed September 30, 2014

Hepatitis C information for the public. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/hepatitis/C/index.htm. Updated May 6, 2014. Accessed September 30, 2014.

Sexual transmission of hepatitis C virus among HIV-infected men who have sex with men—New York City, 2005-2010. MMWR Morb Mortal Wkly Rep. 2011 Jul 22;60:945-50.

Sexually transmitted diseases. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/std/default.htm. Updated September 11, 2014. Accessed September 30, 2014.

What is a blood transfusion? National Heart Lung and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/bt/. Updated January 30, 2012. Accessed September 30, 2014.

What I need to know about hepatitis C. National Digestive Diseases Information Clearinghouse website. Available at: http://digestive.niddk.nih.gov/ddiseases/pubs/hepc%5Fez/. Published April 2009. Updated December 19, 2012. Accessed September 30, 2014.

12/9/2013 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: US Food & Drug Administration. FDA news release: FDA approves new treatment for hepatitis C virus. Food & Drug Administration website. Published November 22, 2013. Accessed December 9, 2013.

4/29/2014 12/9/2013 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: American Association for the Study of Liver Diseases/Infectious Diseases Society of America (AASLD/IDSA) recommendations on testing, managing, and treating hepatitis C. Available at: http://www.hcvguidelines.org/fullreport. Updated March 21, 2014. Accessed September 30, 2014.

10/8/2014 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: British Association of Sexual Health and HIV (BASHH) recommendations on testing for sexually transmitted infections in men who have sex with men. Available at: http://www.bashh.org/documents/BASHH%20Recommendations%20for%20testing%20for%20STIs%20in%20MSM%20-%20FINAL.pdf. Updated 2014. Accessed October 8, 2014.

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