|FDA Warning:||The presence of heavy metals in some Ayurvedic products makes them potentially harmful. Studies have found detectable levels of lead, mercury, and arsenic. Labeled as "Indian" or "South Asian," these products are sold online and in stores. The Food and Drug Administration (FDA) does not review or approve Ayurvedic products, which can be especially harmful to children. For more information, read the FDA's warning .|
1 The Ayurvedic Institute. The Ancient Ayurvedic Writings. Available at: http://www.ayurveda.com/ . Accessed November 5, 2002.
2 Roodenrys S, Booth D, Bulzomi S, et al. Chronic effects of Brahmi ( Bacopa monnieri ) on human memory. Neuropsychopharmacology. 2002;27:279-281.
3 Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology. 2001;156:481-484.
4 Nathan PJ, Clarke J, Lloyd J, et al. The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects. Hum Psychopharmacol. 2001;16:345-351.
5 Maher BF, Stough C, Shelmerdine A, et al. The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humans. Hum Psychopharmacol. 2002;17:163-164.
6 Bharani A, Ganguli A, Mathur LK, et al. Efficacy of Terminalia arjuna in chronic stable angina: a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate. Indian Heart J. 2002;54:170-175.
7 Gupta R, Singhal S, Goyle A, et al. Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomised placebo-controlled trial. J Assoc Physicians India. 2001;49:231-235.
8 Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent—experimental & clinical studies. J Postgrad Med. 1996;42:105-108.
9 Sharma S, Bhargava R, Singhal K. Double blind study to assess the efficacy of in acute rhinitis. Indian J Pharmacol. 1990;22:103-105.
10 Shahani S, Dhadkar VN, Maroli S. The antihistaminic activity of Septilin and its role in topical eosinophillia Indian J Pharmacol. 1993;25:114.
11 Rao CS, Raju C, Gopumadhavan S, et al. Immunotherapeutic modification by an ayurvedic formulation Septilin. Indian J Exp Biol. 1994;32:553-558.
12 Koti ST. Evaluation of Septilin in persistent low-grade infections in school-children: a placebo-controlled study. Probe. 1992;31:325.
13 Agrawal A, Dubey M, Dubey G. Effects of Mentat on memory span, attention, galvanic skin resistance (GSR) and muscle action potential (EMG) among normal adults. Pharmacopsychoecologia. 1990;3:39-42.
14 Dixit S, Agrawal U, Dubey G. Executive fatigue and its management with Mentat. Pharmacopsychoecologia. 1993;6:7-9.
15 Evaluation of BR-16 A (Mentat) in cognitive and behavioural dysfunction of mentally retarded children—a placebo-controlled study. Indian J Pediatr. 1993;60:423-428.
16 Quadri AA. Mentat (BR-16A) in mentally retarded children with behavioral problems. Curr Med Pract. 1993;37:121.
17 Patel RB, Pereira L. Experience with Mentat (BR-16A). Probe. 1991;30:271.
18 D’souza, Chavda KB. Mentat (BR-16A) in hyperactivity and attention deficiency disorders—a double-blind, placebo-controlled study. Probe. 1991;30:227.
19 Dayal RS, Kaira A, Misra MN. Role of Mentat (BR-16A) in behavioural disorders following postnatal organic lesions of the central nervous system (CNS). Probe. 1991;30:305.
20 Sharma K, Kushwaha H, Sharma, S. A placebo-controlled trial on the efficacy of Mentat in managing depressive disorders. Probe. 1993;33:26-31.
21 Banerjee S, Mukherjee A. Mentat (BR-16A)—a herbomineral preparation, as an adjuvant to conventionally used antiepileptic therapy reducing memory loss caused by electroconvulsive therapy (ECT). The Ind Pract. 1994;47:929.
22 Shah LP, Patkar SA. Role of Mentat (BR-16A) in ECT-induced amnesia: a preliminary study. The Ind Pract. 1993;3:225.
23 Ratna M, Abhijeet B, Mrudula A. Seizure control and pattern of behaviour in children with simple febrile convulsions—effect of Mentat syrup. The Ind Pract. 2001;54:729.
24 Agrawal A, Dixit, S, Dubey G. Role of Mentat in the management of post-stroke aphasia. The Ind Pract. 1994;47:211-214.
25 Sharma AK, Agrawal A, Agrawal U, et al . Influence of Mentat (BR-16A) on memory and mental fatigue in cases of anxiety neurosis and depression. Ind J Cancer Res. 1990;3:27.
26 Mani A, Indirabai K, Ramesh S, et al. Double-blind trial of Mentat (BR-16A) in enuresis. The Antiseptic. 1993;90:538.
27 Das DG. A double-blind clinical trial of kamalahar, an indigenous compound preparation, in acute viral hepatitis. Indian J Gastroenterol. 1993;12:126-128.
28 Saxena S, Garg AK, Jain A. Liv.52 in infective hepatitis. A study of Liv.52 therapy in infective hepatitis in children. Current Medical Practice. 1980;5:194.
29 Sama SK, Krishnamurthy L, Ramachandran K, et al. Efficacy of Liv.52 in acute viral hepatitis. A double-blind study. Indian J Med Res. 1976;5:738.
30 Mendal JN, Roy BK. Studies with Liv.52 in the treatment of infective hepatitis, chronic active hepatitis and cirrhosis of the liver. Probe. 1983;22:217.
31 Banerjee P, Mitra SR, Nandi M, et al. A preliminary report on clinical trial of Rumalaya on frozen shoulders. Indian Med J. 1976;70:29.
32 Paranjpe P, Patki P, Patwardhan B. Ayurvedic treatment of obesity: a randomised double-blind, placebo-controlled clinical trial. J Ethnopharmacol. 1990;29:1-11.
33 Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33:91-95.
34 Mohan V. Evaluation of Diabecon (D-400) as an antidiabetic agent—a double blind placebo controlled trial in NIDDM patients with secondary failure to oral drugs. Indian Journal of Clinical Practice. 1998;8:9,18.
35 Lalla JK, Nandedkar SY, Paranjape MH, et al. Clinical trials of ayurvedic formulations in the treatment of acne vulgaris. J Ethnopharmacol. 2001;78:99-102.
36 Chatterjee S. Advances in the pharmacology of anti-infective therapy. Paper presented at: International Symposium, Astra Zeneca Research Foundation and International Society of Anti-Infective Pharmacology; 2000; Bangalore, India.
37 Dahanukar SA, Ogale SB. Paper under publication. Mumbai, India: Seth GS Medical College and KEM Hospital; 1999.
38 Biswas NR, et al. Paper presented at: Centre for Opthalmic Sciences, All India Institute of Medical Sciences; New Delhi, India; 1996.
39 Chopra A, Lavin P, Patwardhan B, et al. Randomized double blind trial of an ayurvedic plant derived formulation for treatment of rheumatoid arthritis. J Rheumatol. 2000;27:1365-1372.
40 Vijayasarathy V, Sharma LK, Prakash ATM. Indigenous drug therapy for haemorrhoids. The Med & Surg. 1981;1-2,22.
41 Vaishali N, Veena S, Dhar H, et al. Double-blind comparative trial of Abana and methyldopa for monotherapy of hypertension in Indian patients. Japanese Heart Journal. 1990;31:193.
42 Antani J, Kulkarni R, Antani N. Effect of Abana on ventricular function in ischaemic heart disease. Japanese Heart Journal. 1990;31:829-835.
43 Damie VB, Gore AG. A controlled trial of Geriforte in post-menopausal depression. The Ind Pract. 1982;35:21.
44 Patnaik BC, Misra SC. The evaluation of Geriforte as a general metabolic tonic in aged persons. The Med & Sur. 1983;6:27.
45 Ganeriwal SK, Reddy BV, Baji PS, et al. The effect of Geriforte on blood chemistry. The Ind Pract. 1981;34:559.
46 Kulsreshtha JK, Handa RK. A clinical study on Geriforte. The Ind. Pract. 1978; 5:247.
47 Gulbranson SH, Hud JA, Hansen RC. Argyria following the use of dietary supplements containing colloidal silver protein. Cutis. 2000;66:373-374,376.
48 de Silva HA, Saparamadu PA, Thabrew MI, et al. Liv.52 in alcoholic liver disease: a prospective, controlled trial. J Ethnopharmacol. 2003;84:47-50.
49 Tait PA, Vors A, James S, et al. Severe congenital lead poisoning in a preterm infant due to a herbal remedy. Med J Aust. 2002;177:193-195.
50 Falkenbach A, Oberguggenberger R. Ayurveda in ankylosing spondylitis and low back pain. Ann Rheum Dis. 2003;62:276-7.
51 Prlic HM, Lehman AJ, Cibere J, et al. Agreement among Ayurvedic practitioners in the identification and treatment of three cases of inflammatory arthritis. Clin Exp Rheumatol. 2003;21:747-52.
52 Nathan PJ, Tanner S, Lloyd J, et al. Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humans. Hum Psychopharmacol. 2004;19:91-96.
53 Hsia SH, Bazargan M, Davidson MB, et al. Effect of Pancreas Tonic (an Ayurvedic herbal supplement) in type 2 diabetes mellitus. Metabolism. 2004;53:1166-73.
54 Saper RB, Kales SN, Paquin J, et al. Heavy metal content of Ayurvedic herbal medicine products. JAMA. 2004;292:2868-2873.
55 Lala LG, D'Mello PM, Naik SR, et al. Pharmacokinetic and pharmacodynamic studies on interaction of "Trikatu" with diclofenac sodium. J Ethnopharmacol. 2004;91:277-80.
56 Huseini HF, Alavian SM, Heshmat R, et al. The efficacy of Liv-52 on liver cirrhotic patients: a randomized, double-blind, placebo-controlled first approach. Phytomedicine. 2005;12:619-24.
57 Murali PM, Rajasekaran S, Krishnarajasekar OR, et al. Plant-based formulation for bronchial asthma: a controlled clinical trial to compare its efficacy with oral salbutamol and theophylline. Respiration. 2005 Nov 22. [Epub ahead of print].
58 van Schalkwyk J, Davidson J, Palmer B, Hope V. Ayurvedic medicine: patients in peril from plumbism. NZMJ. 2006;119. New Zealand Medical Association website. Available at: http://www.nzma.org.nz/journal/abstract.php?id=1958.
59 Elder C, Aickin M, Bauer V, et al. Randomized trial of a whole-system ayurvedic protocol for type 2 diabetes. Altern Ther Health Med. 2006;12:24-30.
60 Chopra A, Lavin P, Patwardhan B, et al. A 32-week randomized, placebo-controlled clinical evaluation of RA-11, an ayurvedic drug, on osteoarthritis of the knees. J Clin Rheumatol. 2006;10:236-245.
61 Rangineni V, Sharada D, Saxena S. Diuretic, hypotensive, and hypocholesterolemic effects of eclipta alba in mild hypertensive subjects: a pilot study. J Med Food. 2007;10:143-148.
62 Prasad KP, Tharangani PG, Samaranayake CN. Recurrent relapses of depression in a patient established on sertraline after taking herbal medicinal mixtures—a herb-drug interaction? J Psychopharmacol. 2008 May 30.
63 Saper RB, Phillips RS, Sehgal A, et al. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA. 2008;300:915-923.
64 Agarwal V, Abhijnhan A, Raviraj P. Ayurvedic medicine for schizophrenia. Cochrane Database Syst Rev. 2007;(4):CD006867.
65 Krishnamurthy MN, Telles S. Assessing depression following two ancient Indian interventions: effects of yoga and ayurveda on older adults in a residential home. J Gerontol Nurs. 2007;33(2):17-23.
66 Sridharan K, Mohan R, Ramaratnam S, Panneerselvam D. Ayurvedic treatments for diabetes mellitus. Cochrane Database Syst Rev. 2011;12:CD008288.